Wednesday, October 26, 2016


ScienceDaily just reported on a mouse study that found that the plant extract rutin helped diminish adiposity (i.e., lose weight):
To make their discovery, Jin and colleagues used both genetically obese mice and mice with diet-induced obesity as models. These mice were fed a regular diet, and supplemental rutin (1 mg/ml) was added to their drinking water. Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both the genetically obese mice and the mice with diet-induced obesity. Specifically, the researchers found that rutin directly binds to and stabilizes SIRT1 (NAD-dependent deacetylase sirtuin-1), leading to hypoacetylation of PGC1α protein, which stimulates Tfam transactivation and eventually augments mitochondrial number and UCP1 activity in BAT. Rutin functions as a cold mimetic through activating a SIRT1-PGC1α-Tfam signaling cascade and increasing mitochondrial number and UCP1 activity in BAT. Rutin also induced brown-like (beige) adipocyte formation in subcutaneous adipose tissue in both obesity mouse models.

Among other things, rutin is an aldose reductase inhibitor. ( Rutin is found in buckwheat, cranberries, citrus fruits, and many other edible plants ( The rutin in buckwheat exhibits chelating and antioxidant activity, too. ( I wonder how buckwheat tastes....

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