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Low levels of choline and high levels of NAA were associated with high IQ.
Statistical analysis showed that the chemicals together could account for 45% of IQ variation. http://news.bbc.co.uk/1/hi/health/388548.stm
N-Acetylaspartic acid, or
N-acetylaspartate (
NAA), is a derivative of
aspartic acid with a formula of C
6H
9NO
5 and a molecular weight of 175.139.
Working memory and N-acetylaspartate level in hippocampus, parietal cortex and subventricular zone
Introduction. Recent studies show that decreased N-acetylaspartate (NAA) level results in memory decline in animals (Xi, 2011) and in humans with mental disorders (Bertolino, 2003; Harris, 2006). In present study we compared memory tests performance and NAA level in different brain structures of healthy subjects. Methods. Subjects: 18 right-handed females (mean age – 59±16) without neurological and mental disorders. All subjects performed working memory tests – verbal and spatial N-back task and visual memory task of complex spatial figures (“snake”). NAA levels in hippocampus, inferior parietal cortex and subventricular zone of both hemispheres were measured with proton magnetic resonance spectroscopy performed with 3T MRI scanner. The received data was analyzed by calculating non-parametric correlations (Spearman, p < 0.05) between individual behavioral and biochemical measurements. Results and conclusions. According to the obtained data, N-back task performance correlates negatively with NAA level in right hippocampus. Moreover, the amount of correct answers in verbal task variation correlates positively (0.71), whereas in spatial task variation the correlation is negative (-0.81). “Snake” test performance correlates positively with NAA level in left hippocampus (0.83). Reaction time in both variations of N-back task correlates negatively (-0.83 for verbal and -0.70 for spatial variations) with NAA level in subventricular zone. No significant correlations between memory tests performance and NAA level in inferior parietal cortex were revealed. Thus, NAA level in both hippocampi and subventricular zone might indicate working memory functioning characteristics in healthy humans.
https://istina.msu.ru/publications/article/1079814/
http://nutritiondata.self.com/foods-000092000000000000000-1.html?
Neuroimage. 2012 Jan 16;59(2):1058-64. doi: 10.1016/j.neuroimage.2011.08.114. Epub 2011 Oct 1.
N-acetylaspartate concentration in corpus callosum is positively correlated with intelligence in adolescents.
- 1
- Istanbul University, Istanbul Faculty of Medicine, Department of Radiology, Capa, Istanbul, Turkey. dr.aydink@superonline.com
Abstract
The corpus callosum is the largest white matter bundle in the brain and integrates inter-hemispheric cortices during sensory-motor and high-order cognitive processes. The aim of the present study was to investigate the associations between the metabolite concentrations in the corpus callosum and intelligence among adolescents. Thirty male adolescents aged between 14 and 16 years were included into the study. We measured the intelligence quotient (IQ) scores of the subjects by using the Wechsler Intelligence Scale for Children-Revised (verbal, performance and full-scale IQ) test. We used proton MR spectroscopy to measure the absolute concentrations of N-acetylasparate (NAA), creatine (Cr) and choline (Cho) in the genu, midbody and isthmus/splenium regions of the corpus callosum. We also measured the whole brain parenchymal size and used it as a confounding factor in the statistical analyses. We assessed the correlations between neurometabolite concentrations and verbal, performance and full-scale IQ scores. We found a significant positive correlation between the whole brain parenchymal size and the full-scale IQ scores. And, the NAA concentration in the isthmus/splenium region was positively correlated with the performance IQ and full-scale IQ scores. NAA is a marker of neuro/axonal integrity. NAA concentration in white matter is related to the structural and functional integrity of axonal fibers. The positive correlation of the IQ scores with the NAA concentrations in the isthmus/splenium region indicates that more efficient inter-hemispheric data transfer between parieto-occipital cortices may enhance intellectual performance.
https://www.ncbi.nlm.nih.gov/pubmed/21983183
Magnetic resonance spectroscopy in social phobia: preliminary findings.
Abstract
Proton localized magnetic resonance spectroscopy was studied in 20 social phobics and 20 age- and sex-matched controls. Stimulated Echo Acquisition Mode volume element localization was used with chemical shift imaging. Choline and creatine signal-to-noise ratios (SNRs) were significantly lower in social phobia than in controls in subcortical, thalamic, and caudate areas. In the social phobic group, N-acetylaspartate (NAA) SNR was significantly lower in cortical and subcortical regions, and ratios of NAA to other metabolites were lower in social phobia. Choline, creatine, and NAA SNRs were inversely correlated to total social phobia and fear symptoms, as measured by the Brief Social Phobia Scale, in the thalamic and noncortical gray areas. In a small number of patients who received clonazepam, posttreatment SNRs generally increased relative to baseline. Our results suggest a promising place for magnetic resonance spectroscopy in social phobia and also indicate potential pharmacodynamic uses of this technique.
https://www.ncbi.nlm.nih.gov/pubmed/8276746
Amino Acids. 2010 May;38(5):1561-9. doi: 10.1007/s00726-009-0369-x. Epub 2009 Nov 5.
Evidence for the involvement of D-aspartic acid in learning and memory of rat.
Abstract
D-Aspartic acid (D-Asp) is an endogenous amino acid present in neuroendocrine systems. Here, we report evidence that D-Asp in the rat is involved in learning and memory processes. Oral administration of sodium D-aspartate (40 mM) for 12-16 days improved the rats' cognitive capability to find a hidden platform in the Morris water maze system. Two sessions per day for three consecutive days were performed in two groups of 12 rats. One group was treated with Na-D-aspartate and the other with control. A significant increase in the cognitive effect was observed in the treated group compared to controls (two-way ANOVA with repeated measurements: F ((2, 105)) = 57.29; P value < 0.001). Five further sessions of repeated training, involving a change in platform location, also displayed a significant treatment effect [F ((2, 84)) = 27.62; P value < 0.001]. In the hippocampus of treated rats, D-Asp increased by about 2.7-fold compared to controls (82.5 +/- 10.0 vs. the 30.6 +/- 5.4 ng/g tissue; P < 0.0001). Moreover, 20 randomly selected rats possessing relatively high endogenous concentrations of D-Asp in the hippocampus were much faster in reaching the hidden platform, an event suggesting that their enhanced cognitive capability was functionally related to the high levels of D-Asp. The correlation coefficient calculated in the 20 rats was R = -0.916 with a df of 18; P < 0.001. In conclusion, this study provides corroborating evidence that D-aspartic acid plays an important role in the modulation of learning and memory.
https://www.ncbi.nlm.nih.gov/pubmed/19890700
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