During the summer of 2016, I was working on a hypothesis
connected to “morning sickness” when I started noticing that trigger food
categories for nausea and vomiting of pregnancy (NVP) often overlapped with reported
migraine trigger foods.
One day I was talking with a friend who informed me that she
often had horrible, disabling migraine headaches that medications did not
relieve; the medications made her feel even worse than the migraines, so she
had stopped taking the medications. As part of my research on NVP, I had formulated
a hypothesis that dietary molybdenum intake in various regions was inversely
correlated with the NVP burden observed in those locales.[i]
So I suggested to my friend that she try molybdenum supplements for her
migraines. She did try them, taking a capsule of 500 mcg of chelated molybdenum glycinate when a migraine first started coming on; it worked dramatically. She has since
found molybdenum effective to not only stop a migraine as it starts but to help
relieve a migraine after it has already become quite painful.
Why did it work for her? And for several other friends and
friends-of-friends who have since used it to ameliorate or end their migraine
suffering? (Molybdenum has also resolved migraine-related nausea in at least two
other women, which could be due to the same mechanism behind molybdenum
alleviating NVP, as mentioned above.) Below is an explanation of how I think
molybdenum intake might help alleviate migraines.
The Molybdoenzyme
Sulfite Oxidase
There are only a handful of known enzymes in the human body
that incorporate element #42, molybdenum,[ii]
an essential trace mineral in the human diet. The most interesting of these molybdenum
enzymes to my research on NVP was sulfite oxidase. Sulfite oxidase catalyzes
the conversion of sulfite to sulfate, which is then recycled or excreted from
the body. Sulfite is toxic to humans; it was formerly used in salad bars to
keep cut produce fresh-looking until it sent many restaurant patrons to the
hospital with severe symptoms that included anaphylactic shock, nausea, abdominal
pain, seizures, and death.[iii]
Feeding rats in such a way as to make them deficient in
molybdenum results in a loss of sulfite oxidase activity.[iv]
Supplementing them with molybdenum in turn increases sulfite oxidase activity
up to a plateau.[v] Molybdenum
is essential for human health, as was discovered when a man kept on
molybdenum-less total parenteral nutrition developed headaches, vomiting, and
heart rhythm abnormalities, and then became comatose; his condition was
reversed when he was given molybdenum.[vi]
A lack of sulfite oxidase in infants causes severe neurological damage and
early death.[vii] [viii]
References
[i]
Taylor CE. A novel treatment for “morning
sickness”: Nausea of pregnancy could be induced by excess sulfite which
molybdenum can help alleviate. Med
Hypotheses 2016;95:31-33.
[ii] Mendel RR. Cell biology of molybdenum. Biochim Biophys Acta - Mol Cell Res 2006;1763(7):621-635.
[iii] Yang WH, Purchase EC. Adverse reactions to sulfites. CMAJ 1985;133(9):865-867, 880.
[iv] Cohen HJ, Drew RT, Johnson JL, Rajagopalan KV. Molecular Basis of the Biological Function of Molybdenum. The Relationship between Sulfite Oxidase and the Acute Toxicity of Bisulfite and SO2. Proc Natl Acad Sci USA 1973;70(12 Pt 1-2):3655-3659.
[v] Wang X, Oberleas D, Yang MT, Yang SP. Molybdenum requirement of female rats. J Nutr 1992;122(4):1036-1041.
[vi] Abumrad NN, Schneider AJ, Steel D, Rogers LS. Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. Am J Clin Nutr 1981;34(11):2551-2559.
[vii] Johnson-Winters K, Tollin G, Enemark JH. Elucidating the Catalytic Mechanism of Sulfite Oxidizing Enzymes using Structural, Spectroscopic and Kinetic Analyses. Biochem 2010;49(34):7242-7254.
[viii] Dublin AB, Hald JK, Wootton-Gorges SL. Isolated Sulfite Oxidase Deficiency: MR Imaging Features. AJNR 2002;23:484-485.
(Disclaimer: I do not prescribe the use of pharmaceutical drugs in any way. I am not a physician, and I reject out of hand any attempt to hold me liable for what boils down to a discussion of food. Any use of a molybdenum supplement should be prudent and guided by the tested tolerable upper intake levels for its usage (see http://lpi.oregonstate.edu/mic/minerals/molybdenum for those limits). Any use of an isolated molybdenum supplement during pregnancy should be under the direction of a medical professional as such supplements have apparently not been tested during pregnancy.)
[ii] Mendel RR. Cell biology of molybdenum. Biochim Biophys Acta - Mol Cell Res 2006;1763(7):621-635.
[iii] Yang WH, Purchase EC. Adverse reactions to sulfites. CMAJ 1985;133(9):865-867, 880.
[iv] Cohen HJ, Drew RT, Johnson JL, Rajagopalan KV. Molecular Basis of the Biological Function of Molybdenum. The Relationship between Sulfite Oxidase and the Acute Toxicity of Bisulfite and SO2. Proc Natl Acad Sci USA 1973;70(12 Pt 1-2):3655-3659.
[v] Wang X, Oberleas D, Yang MT, Yang SP. Molybdenum requirement of female rats. J Nutr 1992;122(4):1036-1041.
[vi] Abumrad NN, Schneider AJ, Steel D, Rogers LS. Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. Am J Clin Nutr 1981;34(11):2551-2559.
[vii] Johnson-Winters K, Tollin G, Enemark JH. Elucidating the Catalytic Mechanism of Sulfite Oxidizing Enzymes using Structural, Spectroscopic and Kinetic Analyses. Biochem 2010;49(34):7242-7254.
[viii] Dublin AB, Hald JK, Wootton-Gorges SL. Isolated Sulfite Oxidase Deficiency: MR Imaging Features. AJNR 2002;23:484-485.
(Disclaimer: I do not prescribe the use of pharmaceutical drugs in any way. I am not a physician, and I reject out of hand any attempt to hold me liable for what boils down to a discussion of food. Any use of a molybdenum supplement should be prudent and guided by the tested tolerable upper intake levels for its usage (see http://lpi.oregonstate.edu/mic/minerals/molybdenum for those limits). Any use of an isolated molybdenum supplement during pregnancy should be under the direction of a medical professional as such supplements have apparently not been tested during pregnancy.)
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