Molybdenum
supplements for nausea and vomiting from gastrointestinal viruses
During the first part of 2016, I authored a medical
hypothesis connecting less severe “morning sickness”—nausea and vomiting of
pregnancy (NVP)—with high regional intake of foods containing relatively high
levels of the essential micronutrient molybdenum.[i]
My sister purchased a bottle of the molybdenum supplement
“Moly-B” to have on hand in case she became pregnant. She did not get pregnant,
but she and a friend contracted a gastrointestinal virus, and she decided to
try the molybdenum for the nausea and vomiting caused by the virus (her husband was already vomiting from it). As a result
of taking the molybdenum early in the course of the infection, she and her friend completely avoided any vomiting
and passed the virus quickly.
Since my sister’s serendipitous discovery, approximately 70
people (at least that I know of) have used molybdenum supplements
to either completely avoid vomiting from “stomach bugs” or to cut short the duration
of vomiting from “stomach bugs” after it had already begun. The effects are
clear and dramatic and go far beyond what one would expect from a placebo
effect. Molybdenum, if taken during the early stomach cramping stage
of a gastrointestinal virus infection, has been to my knowledge uniformly
successful at preventing vomiting. Furthermore, molybdenum taken during the
vomiting stage has also shown itself effective to shorten the duration of the
vomiting stage, although larger doses seem to be required than if molybdenum had
been taken earlier.
The dosages people have been taking for this purpose are typically
10-20 times larger than the established RDA for molybdenum, yet still
below the established tolerable upper intake level. Moreover, the molybdenum is
only used on as “as-needed” basis, not chronically. Two other brands of
molybdenum supplements have also been used by people I know, and all three molybdenum supplement
brands show approximately the same effectiveness.
How is molybdenum having this effect? Correlation argues
best for causation where there is a plausible causative mechanism, and below is
a suggestion of how I think molybdenum might be alleviating nausea and vomiting
from gastrointestinal viruses.
The Molybdoenzyme
Sulfite Oxidase and Sulfite
There are only five known enzymes in the human body that
incorporate element #42, molybdenum,[ii]
an essential trace mineral in the human diet. The most interesting of these
molybdenum enzymes to my research on NVP was sulfite oxidase. Sulfite oxidase
catalyzes the conversion of sulfite to sulfate, which is then recycled or
excreted from the body. Sulfite is toxic to humans; it was formerly used in
salad bars to keep cut produce fresh-looking until it sent many restaurant
patrons to the hospital with severe symptoms that included anaphylactic shock, nausea,
abdominal pain, seizures, and death.[iii]
Feeding rats in such a way as to make them deficient in
molybdenum results in a loss of sulfite oxidase activity.[iv]
Supplementing them with molybdenum, on the other hand, increases sulfite
oxidase activity up to a plateau.[v]
Molybdenum is essential for human health, as was discovered when a man kept on
molybdenum-less total parenteral nutrition developed headaches, vomiting, and
heart rhythm abnormalities, and then became comatose; his condition was
reversed when he was given molybdenum.[vi]
References
[i]
Taylor CE. A novel treatment for “morning
sickness”: Nausea of pregnancy could be induced by excess sulfite which
molybdenum can help alleviate. Med
Hypotheses 2016;95:31-33.
[ii] Mendel
RR. Cell biology of molybdenum. Biochim
Biophys Acta - Mol Cell Res 2006;1763(7):621-635.
[iii] Yang WH,
Purchase EC. Adverse reactions to sulfites. CMAJ
1985;133(9):865-867, 880.
[iv] Cohen HJ, Drew RT, Johnson
JL, Rajagopalan KV. Molecular Basis of the Biological Function of Molybdenum.
The Relationship between Sulfite Oxidase and the Acute Toxicity of Bisulfite
and SO2. Proc Natl
Acad Sci USA 1973;70(12 Pt 1-2):3655-3659.
[v]
Wang X, Oberleas D, Yang MT, Yang SP. Molybdenum requirement of female rats. J Nutr 1992;122(4):1036-1041.
[vi]
Abumrad NN, Schneider AJ, Steel D, Rogers LS. Amino acid intolerance during
prolonged total parenteral nutrition reversed by molybdate therapy. Am J Clin Nutr 1981;34(11):2551-2559.
(Disclaimer: I do not prescribe the use of pharmaceutical drugs in any way. I am not a physician, and I reject out of hand any attempt to hold me liable for what boils down to a discussion of food. Any use of a molybdenum supplement should be prudent and guided by the tested tolerable upper intake levels for its usage (see http://lpi.oregonstate.edu/mic/minerals/molybdenum for those limits). Any use of an isolated molybdenum supplement during pregnancy should be under the direction of a medical professional as such supplements have apparently not been tested during pregnancy.)
(Disclaimer: I do not prescribe the use of pharmaceutical drugs in any way. I am not a physician, and I reject out of hand any attempt to hold me liable for what boils down to a discussion of food. Any use of a molybdenum supplement should be prudent and guided by the tested tolerable upper intake levels for its usage (see http://lpi.oregonstate.edu/mic/minerals/molybdenum for those limits). Any use of an isolated molybdenum supplement during pregnancy should be under the direction of a medical professional as such supplements have apparently not been tested during pregnancy.)
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