Saturday, December 30, 2017

H2S --> sulfite and advances in understanding H2S metabolism

One of the points in my hypotheses about why molybdenum is helping people with nausea and migraines (and apparently "morning sickness," though I have fewer pregnant friends than friends with migraines) is that the molybdenum is enabling higher activity of the sulfite oxidase enzyme--which uses a molybdenum cofactor--in transforming toxic sulfite to excretable sulfate. But where is the sulfite coming from? I think it's a metabolic product of hydrogen sulfide (H2S), which it turns out is important to making new blood vessels from existing ones (angiogenesis), vasodilation, and even keeping uterine muscles from contracting.

The pathways by which H2S is broken down in the body are still being clarified by researchers. Sulfite is often an end result, but sulfite is also used by the catabolism. Therefore, whether there is a net increase in sulfite from H2S catabolism is far from a given. A study published this past year by some Polish* researchers found that there appears to be a non-canonical pathway by which H2S is oxidized in the brain, and that pathway appears to use neuroglobin. (https://www.ncbi.nlm.nih.gov/pubmed/28632164) Guess where neuroglobin shows up besides in the brain? In the stomach and the small intestine! (https://www.ncbi.nlm.nih.gov/pubmed/20828399) The two body regions where I've been observing molybdenum to have an effect on mysterious illnesses--nausea/vomiting and migraines--are also places where an unknown H2S catabolic pathway appears to be occurring. I look forward to more research on neuroglobin's interaction with H2S.

* I love Poland. Lots of easily-utilized glycine betaine in the national diet, and cutting edge research in very interesting fields.

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